Arimistane

Description

Arimistane, also known as Androsta-3,5-diene-7,17-dione, is a synthetic steroidal aromatase inhibitor belonging to the androstane chemical class. It has been investigated for its ability to inhibit aromatase, the enzyme responsible for converting androgens such as testosterone and androstenedione into estrogens. By influencing this enzymatic pathway, Arimistane has been studied as a tool for understanding estrogen biosynthesis and androgen–estrogen balance.

Aromatase inhibition is an established area of endocrine research because estrogen signaling plays important roles in reproductive biology, bone metabolism, adipose tissue regulation, and feedback control of the hypothalamic–pituitary–gonadal axis. Arimistane has been researched primarily for its effects on estrogen-related pathways, although its complete pharmacological profile and long-term biological effects are not fully characterized. Unlike non-steroidal aromatase inhibitors, Arimistane is structurally related to steroidal aromatase inhibitors and may interact with aromatase through mechanisms involving enzyme inhibition.

Product Specifications

• Compound / Peptide name: Arimistane (Androsta-3,5-diene-7,17-dione)
• Classification: Steroidal aromatase inhibitor / synthetic small molecule
• Sequence: Not applicable
• Molecular Formula: C19H24O2
• Molecular Weight: 284.39 g/mol
• CAS Number: 1420-49-1
• PubChem CID: 159284
• Form: Tablet
• Strength: 25 mg per tablet
• Appearance: Tablet form
• Storage: Store according to supplier specifications
• Solubility: Research-dependent; compound solubility varies according to experimental conditions
• Regulatory Status: Investigational research compound; not approved for human therapeutic use

What Is It Used For and Its Purpose 

Arimistane is primarily studied in endocrine and molecular pharmacology research for its ability to modulate aromatase activity and influence estrogen biosynthesis. Researchers investigate aromatase inhibitors to better understand hormonal regulation, steroid metabolism, and the physiological consequences of altered androgen-to-estrogen conversion.

The compound has been examined in contexts involving endocrine signaling, including the relationship between androgen production, estrogen formation, and feedback mechanisms within hormone-regulated systems. Research interest also extends to understanding how aromatase inhibition may affect tissues where estrogen signaling contributes to biological regulation.

Potential research applications include: 

• Endocrinology and hormone regulation research
• Aromatase enzyme inhibition studies
• Estrogen biosynthesis research
• Androgen–estrogen signaling pathways
• Steroid metabolism research
• Body composition and metabolic research

Potential Scientific Benefits 

Research on Arimistane has focused primarily on its ability to inhibit aromatase, an enzyme involved in estrogen production. By reducing aromatase-mediated conversion of androgens into estrogens, aromatase inhibitors provide a model for investigating estrogen regulation and endocrine feedback mechanisms. Biochemical studies of aromatase inhibitors demonstrate that modulation of estrogen biosynthesis can alter hormone signaling pathways. However, specific findings related to Arimistane in humans remain limited, and effects on testosterone concentrations, body composition, muscle retention, or recovery require further controlled investigation.

Arimistane has also been described as having potential effects on glucocorticoid-related pathways, including possible interactions with cortisol regulation. In endocrine research, aromatase inhibition provides valuable insight into the roles of estrogen signaling in tissues such as bone, reproductive organs, and metabolic systems. The physiological outcomes of altering these pathways depend on dose, duration, tissue distribution, and individual biological factors.

Reported research areas and mechanisms include:

• Aromatase enzyme inhibition and estrogen biosynthesis regulation
• Investigation of androgen-to-estrogen conversion pathways
• Study of endocrine feedback mechanisms
• Research into steroid hormone metabolism
• Evaluation of estrogen receptor-related physiological processes
• Investigation of hormone signaling interactions in biological models

Current evidence remains limited, and further well-controlled clinical studies are required to establish long-term efficacy and safety in humans.

Research Data Sheet 

• Compound / Peptide name: Arimistane (Androsta-3,5-diene-7,17-dione)
• Sequence: Not applicable
• Classification: Steroidal aromatase inhibitor / small molecule
• Molecular Formula: C19H24O2
• Molecular Weight: 284.39 g/mol
• CAS Number: 1420-49-1
• PubChem CID: 159284
• Form: Tablet
• Purity: 99%
• Storage: Store according to supplier specifications
• Research Categories: Aromatase inhibition; endocrine signaling; steroid metabolism; estrogen regulation

Safety Precautions 

Arimistane is supplied strictly for laboratory research purposes and should only be handled by qualified researchers using appropriate laboratory procedures. Hormone-modulating compounds require careful handling because endocrine pathways are complex and may produce biological effects that are not fully understood.

• Research use only
• Not for human consumption
• Not intended to diagnose, treat, or prevent disease
• Use appropriate PPE, including gloves, laboratory coat, and eye protection
• Follow appropriate laboratory handling procedures
• Maintain proper storage conditions according to supplier recommendations
• Avoid repeated freeze–thaw cycles where applicable
• Ensure proper labeling and documentation of research materials
• Dispose of waste according to applicable laboratory regulations
• Limited human safety data are available
• Potential unknown long-term endocrine effects remain under investigation

Conclusion 

Arimistane is an investigational aromatase inhibitor studied for its role in regulating estrogen biosynthesis and understanding androgen–estrogen interactions. Its primary scientific relevance comes from its ability to modulate a key enzymatic pathway involved in steroid hormone metabolism. Research involving Arimistane contributes to broader investigations into endocrine regulation, aromatase activity, and hormone-responsive biological systems. While aromatase inhibition is a well-established research area, specific long-term physiological effects of Arimistane require further characterization. The compound remains a tool for investigating hormone signaling pathways, steroid metabolism, and endocrine biology.