SR-9009 (Stenabolic)

Description

What is SR-9009? 

SR-9009, commonly referred to as Stenabolic, is an synthetic small molecule developed as an agonist of the nuclear receptors Rev-Erbα (NR1D1) and, to a lesser extent, Rev-Erbβ (NR1D2). Unlike selective androgen receptor modulators (SARMs), SR-9009 does not interact with androgen receptors and instead serves as a pharmacological tool for investigating circadian biology, energy metabolism, and transcriptional regulation mediated by Rev-Erb receptors.

Rev-Erb receptors are ligand-regulated transcription factors involved in the regulation of circadian rhythms, mitochondrial function, lipid metabolism, glucose homeostasis, inflammatory signaling, and cellular energy balance. Activation of these receptors has been investigated for its influence on metabolic gene expression and physiological adaptation in tissues including skeletal muscle, liver, adipose tissue, and macrophages. Experimental models have explored its effects on metabolic regulation, mitochondrial activity, exercise-associated physiology, and circadian gene expression.

• Compound / Peptide name: SR-9009 (Stenabolic)
• Classification: Synthetic Rev-Erbα/Rev-Erbβ agonist (small molecule)
• Sequence (if applicable): Not applicable
• Form: Tablet
• Strength: 10 mg per tablet
• Purity: 99%
• Appearance: Tablet form
• Storage: Store in a cool, dry place according to supplier recommendations
• Solubility: Research-dependent
• Regulatory Status: Investigational research compound; not approved for human therapeutic use

What Is It Used For and Its Purpose 

SR-9009 is primarily employed as a research compound for investigating the biological functions of Rev-Erb nuclear receptors and their role in circadian regulation, metabolic homeostasis, and energy utilization. Researchers use SR-9009 to better understand transcriptional pathways that coordinate cellular metabolism across multiple tissues.

Experimental studies have examined SR-9009 in models involving skeletal muscle metabolism, hepatic lipid regulation, glucose homeostasis, mitochondrial biology, and inflammatory signaling. These investigations provide insights into how Rev-Erb receptor activation influences physiological adaptation and metabolic gene expression.

Because circadian rhythms regulate numerous metabolic and endocrine processes, SR-9009 has become an important research tool in studies exploring interactions between biological clocks, mitochondrial function, and whole-body metabolism.

Research Application

• Circadian biology
• Metabolism research
• Mitochondrial function
• Lipid metabolism
• Glucose metabolism
• Nuclear receptor signaling
• Exercise physiology
• Skeletal muscle biology
• Inflammation research
• Molecular pharmacology

Potential Scientific Benefits 

Studies have demonstrated that SR-9009 activates Rev-Erb nuclear receptors, resulting in altered transcription of genes involved in circadian regulation, mitochondrial function, lipid metabolism, and energy homeostasis. These biological effects have been characterized primarily through laboratory and animal research. Investigations have reported changes in metabolic activity, increased oxidative metabolism, and altered expression of genes associated with mitochondrial function following Rev-Erb activation. Some studies have observed improvements in endurance capacity and exercise-associated physiological parameters.

Research has also explored the influence of SR-9009 on hepatic lipid metabolism, glucose regulation, and inflammatory pathways. Activation of Rev-Erb receptors has been associated with modulation of inflammatory gene expression and regulation of metabolic pathways involved in fatty acid utilization.

Claims that SR-9009 functions as “exercise in a bottle,” reliably induces significant fat loss, or consistently increases mitochondrial biogenesis. Furthermore, the pharmacokinetic characteristics of SR-9009, including its relatively short half-life observed in preclinical studies, have not been comprehensively characterized.

Observed biological activities in research

• Activation of Rev-Erb nuclear receptors
• Regulation of circadian clock-associated gene expression
• Investigation of mitochondrial metabolic pathways
• Modulation of lipid metabolism
• Effects on glucose homeostasis in experimental models
• Investigation of inflammatory signaling pathways
• Evaluation of exercise-related metabolic adaptation

Molecular mechanisms reported

• Rev-Erbα and Rev-Erbβ agonism
• Transcriptional regulation of circadian genes
• Modulation of metabolic gene expression
• Influence on pathways governing cellular energy homeostasis

Physiological pathways involved

• Circadian rhythm regulation
• Mitochondrial metabolism
• Lipid homeostasis
• Glucose metabolism
• Skeletal muscle oxidative metabolism
• Inflammatory signaling

Experimental outcomes in models

• Altered metabolic gene expression
• Enhanced oxidative metabolism in animal studies
• Investigation of endurance-related physiological responses
• Modulation of circadian regulatory pathways

Current evidence remains limited, and further well-controlled clinical studies are required to establish long-term efficacy and safety in humans.

Research Data Sheet 

• Compound / Peptide name: SR-9009 (Stenabolic)
• Sequence (if applicable): Not applicable
• Classification: Rev-Erbα/Rev-Erbβ agonist
• Form: Tablet
• Appearance: Tablet form
• Purity: 99%
• Solubility: Research-dependent
• Storage: Store in a cool, dry place according to supplier recommendations
• Research Categories: Circadian biology, metabolism, mitochondrial function, lipid metabolism, glucose metabolism, exercise physiology, inflammation research

Safety Precautions 

SR-9009 is supplied exclusively for laboratory research and should only be handled by qualified personnel following established laboratory safety procedures. As an investigational Rev-Erb receptor agonist, the long-term biological effects of SR-9009 remain incompletely characterized. Researchers should follow appropriate laboratory protocols for handling, storage, documentation, and disposal throughout all experimental work.

• Research use only
• Not for human consumption
• Not intended to diagnose, treat, or prevent disease
• Wear appropriate personal protective equipment, including gloves, laboratory coat, and eye protection
• Follow aseptic laboratory handling procedures where appropriate
• Store under recommended laboratory storage conditions
• Avoid unnecessary freeze–thaw cycles where applicable
• Maintain accurate labeling and documentation
• Dispose of waste according to institutional and regulatory laboratory requirements
• Limited human safety data available
• Potential unknown long-term biological effects

Conclusion 

SR-9009 (Stenabolic) is an investigational Rev-Erb receptor agonist that has become a valuable research tool for studying circadian biology, metabolic regulation, and nuclear receptor signaling. Its unique mechanism distinguishes it from androgen receptor modulators by targeting transcriptional pathways that regulate cellular energy metabolism and biological rhythms.

Current scientific knowledge is based predominantly on laboratory experiments and studies investigating mitochondrial metabolism, lipid utilization, inflammatory signaling, and circadian gene regulation. SR-9009 continues to contribute to translational biomedical research aimed at elucidating the molecular mechanisms governing metabolic homeostasis and circadian regulation.