Guides

In-Depth Article: 10+ Disadvantages of NAD+ 500mg

Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme involved in cellular metabolism, DNA repair, and energy production. While interest in NAD+ supplementation, including high doses such as 500mg vials, continues to grow in research and wellness communities, it’s important to critically evaluate the potential drawbacks and risks — especially at higher doses or outside controlled environments. Below are more than ten detailed disadvantages and safety considerations based on current scientific understanding and reports.

1) Poor...

The Unvarnished Truth About BPC-157: A Deep Dive Into Its Potential Side Effects and Risks

BPC-157 (Body Protecting Compound-157) has emerged as one of the most controversial and discussed Peptides in the biohacking and performance enhancement communities. Marketed as a "healing peptide" derived from human gastric juice, it has achieved near-mythical status for its purported ability to repair tendons, heal gut lining, and accelerate recovery from injuries. However, beneath the compelling anecdotal reports lies a complex pharmacological agent with a poorly characterized safety profile in humans. This comprehensive...

Harmful Effects and Safety Risks of Glow-Blend-70 mg

Glow Blend 70mg is a peptide research blend composed of GHK-Cu (Copper Tripeptide-1), BPC-157, and TB-500, distributed as a lyophilized compound for research and laboratory use only. While these peptides are individually studied for regenerative, healing, and cellular signaling properties in experimental models, Glow-Blend-70 mg is not approved for human or veterinary use, nor is it classified as a medication, dietary supplement, or cosmetic product. Despite growing interest in peptide research compounds, Glow-Blend-70...

Melanotan-2 (MT2) 10mg — Side Effects You Should Know

Melanotan-2 (MT2) is a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH), a naturally occurring peptide involved in pigmentation, appetite regulation, sexual function, and immune response. Originally developed for research into photoprotection and pigmentation disorders, MT2 has since gained attention through unregulated markets, often promoted for tanning, libido enhancement, and appetite suppression. Despite its popularity in non-clinical settings, Melanotan-2 is not approved for human use by the FDA, EMA, MHRA, or any major regulatory authority. Products...

Important Health Considerations When Evaluating RAD-150

RAD-150, also known as TLB-150, is a next-generation selective androgen receptor modulator (SARM) derived from RAD-140. It has been structurally modified to increase stability and half-life, which may enhance potency and duration of action. While these characteristics are often highlighted for performance-related purposes, they also introduce important health considerations that must not be overlooked. RAD-150 is not approved for human consumption, and there are no large-scale clinical trials confirming its safety in humans....

Unintended Effects and Warnings for GHK-Cu

GHK-Cu (Glycyl-L-histidyl-L-lysine copper) is a naturally occurring peptide complex used widely in research contexts, skincare formulations, and experimental therapies due to its regenerative and anti-aging properties. Although studies and decades of topical use show a generally favorable safety profile, there are several unintended effects, cautions, and warnings that researchers, clinicians, and potential users should be aware of before using products such as GHK-Cu.

1. Local Skin Irritation and Redness

One of the most commonly reported...

The Downsides No One Talks About: A Comprehensive Look at LGD-4033 (Ligandrol)

LGD-4033 (Ligandrol) has earned a strong reputation in the performance enhancement world for its ability to promote lean muscle mass, strength gains, and improved physical performance. Often marketed as a “safer alternative” to anabolic steroids, it is frequently described as selective, mild, and well-tolerated. However, what often gets overlooked are the less glamorous realities that come with LGD-4033 use. While it may not carry the same immediate risks as traditional anabolic steroids,

Ipamorelin 10 mg: Side Effects You Should Know

Ipamorelin is a synthetic peptide classified as a growth hormone secretagogue (GHS)—a compound that stimulates the release of growth hormone from the pituitary gland. Unlike some older secretagogues, ipamorelin is often marketed for its “selective” action, resulting in fewer hormonal disruptions compared with related peptides. However, despite its reputed tolerability, a range of side effects has been documented across clinical sources and user reports. Importantly, Ipamorelin is not FDA-approved for general human use and...

Stenabolic SR-9009 Explained – Key Benefits and Performance Potential

Stenabolic, commonly referred to as SR-9009, is a synthetic compound developed for research into metabolic regulation and circadian rhythms. Contrary to common marketing claims, SR-9009 is not a SARM (Selective Androgen Receptor Modulator); instead, it functions as a Rev-Erbα agonist, a type of molecule that influences gene expression linked to energy metabolism. Originally synthesized to explore potential therapeutic applications — including metabolic disorders — SR-9009 has gained attention in athletic and fitness...

Critical Review – The Risks of Cardarine (GW-501516)

Cardarine, scientifically known as GW-501516, is a synthetic research compound originally developed for the study of metabolic and cardiovascular disorders. It functions as a potent agonist of the peroxisome proliferator-activated receptor delta (PPAR-δ), a nuclear receptor involved in the regulation of energy balance, fatty acid oxidation, and endurance-related metabolic pathways. Unlike anabolic agents or selective androgen receptor modulators (SARMs), Cardarine does not interact with androgen receptors and is classified as a metabolic...