5-Amino-1MQ – 5mg

Description

5-Amino-1MQ is a small molecule researched for its potential to inhibit nicotinamide N-methyltransferase (NNMT), an enzyme linked to fat metabolism, cellular energy balance, and overall metabolic regulation. NNMT is highly expressed in adipose tissue and has emerged as an important metabolic regulator in obesity, insulin resistance, aging, and several chronic disease models. By inhibiting NNMT activity, 5-Amino-1MQ has been investigated for its potential to alter intracellular nicotinamide metabolism, increase nicotinamide adenine dinucleotide (NAD⁺) availability, and improve mitochondrial energy utilization.

5-Amino-1MQ remains an investigational research compound and has not been approved as a therapeutic drug by major regulatory authorities. It is supplied exclusively for laboratory research involving qualified investigators studying metabolic biology, adipose tissue physiology, and enzyme signaling pathways.

Product Specifications

• Form: Lyophilised powder
• Total Quantity: 5mg per vial
• Strength: Research grade
• Purity: ≥ 98%
• Appearance: White/off-white powder
• Storage: −20 °C, protected from light and moisture

What Is It Used For and Its Purpose 

5-Amino-1MQ is primarily used as a research tool to investigate the biological functions of nicotinamide N-methyltransferase (NNMT), an enzyme increasingly recognized for its role in regulating energy metabolism and adipose tissue biology. NNMT has become a significant focus in metabolic research due to its association with obesity, insulin resistance, aging, and altered mitochondrial function.

By selectively inhibiting NNMT activity, researchers study how changes in nicotinamide metabolism influence intracellular NAD⁺ availability, methylation balance, mitochondrial efficiency, and lipid metabolism. These investigations provide insight into mechanisms that regulate energy expenditure, adipocyte function, and metabolic homeostasis.

Beyond obesity research, 5-Amino-1MQ has also been explored in studies involving regenerative biology, cellular senescence, fibrosis, and cancer metabolism, where NNMT expression has been associated with altered cellular metabolic states.

Research Applications

• Metabolism and metabolic regulation
• Obesity and adipose tissue biology
• Cellular energy metabolism
• Mitochondrial function
• NAD⁺ metabolism
• Enzyme inhibition studies
• Epigenetic and methylation research
• Aging and longevity research
• Regenerative medicine
• Cell signaling and metabolic physiology

Potential Scientific Benefits

Current scientific evidence indicates that 5-Amino-1MQ functions as a selective inhibitor of nicotinamide N-methyltransferase, providing researchers with an important tool for investigating metabolic regulation at the cellular level. Most published evidence has been generated using in vitro experiments and animal models, with limited human clinical data currently available.

Experimental studies suggest that inhibition of NNMT may increase intracellular nicotinamide availability, thereby supporting NAD⁺ biosynthesis and improving mitochondrial oxidative metabolism. Because NAD⁺ is a critical cofactor for cellular energy production, DNA repair, and sirtuin activity, modulation of this pathway has attracted growing interest in metabolic disease and healthy aging research.

Animal studies have also reported reductions in adipocyte size, improvements in whole-body energy expenditure, and altered lipid metabolism following pharmacological NNMT inhibition. Additional investigations suggest potential effects on insulin sensitivity, hepatic lipid accumulation, and inflammatory signaling, although these findings remain under active investigation and should not be interpreted as established therapeutic outcomes.

Emerging evidence further indicates that NNMT may influence epigenetic regulation through its effects on cellular methyl donor availability. Consequently, 5-Amino-1MQ has become increasingly valuable for researchers studying the relationship between metabolism, gene regulation, and cellular differentiation.

Biological Activities Observed in Studies

• Selective inhibition of nicotinamide N-methyltransferase (NNMT)
• Increased intracellular nicotinamide availability
• Modulation of NAD⁺ metabolic pathways
• Enhanced mitochondrial energy metabolism in experimental models
• Reduced adipocyte hypertrophy in preclinical studies
• Altered lipid metabolism and fatty acid utilization
• Investigation of cellular methylation pathways
• Potential influence on metabolic flexibility
• Evaluation of adipose tissue remodeling mechanisms
• Research applications in aging and regenerative biology

Current evidence remains limited, and further well-controlled clinical studies are required to establish long-term efficacy and safety in humans.

Research Data Sheet 

5-Amino-1MQ is a synthetic small-molecule NNMT inhibitor widely used in experimental studies of metabolism, mitochondrial biology, and adipose tissue physiology.

• Compound: 5-Amino-1MQ
• Chemical Name: 5-Amino-1-methylquinolinium derivative (research designation)
• Classification: Nicotinamide N-methyltransferase (NNMT) inhibitor
• Molecular Formula: Not consistently reported in standard public databases
• Molecular Weight: Not consistently reported in standard public databases
• CAS Number: Not consistently assigned
• PubChem CID: Not consistently assigned
• ChemSpider ID: Not consistently assigned
• ChEMBL ID: Not consistently assigned
• Form: Lyophilized powder
• Appearance: White to off-white powder
• Strength: 5 mg per vial
• Purity: ≥98%
• Solubility: Soluble in aqueous laboratory buffers and DMSO (depending on research protocol)
• Storage: Refrigerate at 2–8°C; long-term storage at -20°C is recommended
• Research Categories: Metabolism, obesity research, mitochondrial biology, enzyme inhibition, NAD⁺ metabolism, regenerative medicine, aging research

Safety Precautions 

5-Amino-1MQ is supplied exclusively for laboratory research and should be handled only by qualified professionals familiar with the safe handling of investigational research chemicals.

As a research molecule with limited human safety data, appropriate laboratory procedures should be followed throughout preparation, storage, experimental use, and disposal. Experimental protocols should comply with institutional safety guidelines and applicable regulations.

• Research use only
• Not for human consumption
• Not intended to diagnose, treat, cure, or prevent disease
• Wear appropriate personal protective equipment (laboratory coat, gloves, and eye protection)
• Handle using aseptic laboratory techniques where appropriate
• Store under recommended refrigeration or frozen conditions
• Avoid repeated freeze–thaw cycles after reconstitution
• Clearly label all prepared solutions and research samples
• Dispose of waste according to institutional and local laboratory regulations
• Human safety, pharmacokinetic, and long-term toxicology data remain limited

Conclusion 

5-Amino-1MQ has emerged as an important investigational compound for studying nicotinamide N-methyltransferase and its role in metabolic regulation. As understanding of NNMT biology has expanded, this small-molecule inhibitor has become a valuable research tool for exploring how cellular energy metabolism, NAD⁺ homeostasis, and methylation pathways contribute to obesity, aging, and metabolic disease.

Preclinical research indicates that NNMT inhibition may influence adipose tissue function, mitochondrial efficiency, and intracellular energy utilization through mechanisms distinct from traditional endocrine or appetite-regulating pathways. These characteristics make 5-Amino-1MQ particularly useful for mechanistic studies focused on metabolic physiology and cellular bioenergetics.

Although early findings are encouraging, the majority of available evidence is derived from laboratory and animal research. Additional well-designed clinical studies are required to determine the long-term biological significance and potential translational applications of NNMT inhibition in humans.