Kisspeptin 10mg

Description

Kisspeptin is a naturally occurring neuropeptide family derived from the KISS1 gene and is a key regulator of the hypothalamic–pituitary–gonadal (HPG) axis. The most extensively studied active fragment is kisspeptin-10 (Kp-10), a ten-amino-acid peptide derived from the larger kisspeptin-54 molecule. Kisspeptin peptides are produced primarily by specialized neurons within the hypothalamus and act as important upstream regulators of reproductive hormone signaling.

The primary mechanism of action involves activation of the kisspeptin receptor (KISS1R, also known as GPR54), a G protein-coupled receptor expressed on gonadotropin-releasing hormone (GnRH) neurons. Activation of KISS1R stimulates GnRH secretion, which subsequently regulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. This signaling pathway is essential for normal reproductive endocrine function, puberty initiation, and regulation of fertility-associated processes.

Beyond reproductive biology, KISS1R expression has been identified in several peripheral tissues, leading to research into additional biological roles. Studies have investigated kisspeptin involvement in metabolic regulation, pancreatic islet function, neural signaling, inflammation-associated pathways, liver biology, and adipose tissue metabolism. Many of these functions remain under investigation, and the precise physiological significance of peripheral kisspeptin signaling is not fully characterized.

Kisspeptin has progressed beyond basic laboratory research, with human studies evaluating its role in reproductive endocrinology, including investigation of GnRH neuron function, reproductive hormone regulation, and assisted reproductive technologies.

Product Specifications

• Peptide Name: Kisspeptin-10 (Kp-10; Human Metastin 45-54)
• Classification: Synthetic neuropeptide fragment
• Sequence: H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
• Molecular Formula: C₆₃H₈₃N₁₇O₁₄
• Molecular Weight: 1302.4 g/mol
• CAS Number: 374675-21-5
• PubChem CID: Not consistently reported in public databases
• ChemSpider ID: Not consistently reported in public databases
• ChEMBL ID: Not available
• Form: Lyophilized peptide powder
• Strength: 10 mg
• Appearance: Typically supplied as a white to off-white lyophilized powder
• Storage: Store refrigerated at 2–8°C for short-term storage; long-term storage conditions depend on supplier specifications
• Solubility: Research-dependent
• Regulatory Status: Investigational research peptide; not approved as a therapeutic drug

What Is It Used For and Its Purpose 

Kisspeptin is primarily investigated as a regulator of reproductive neuroendocrine signaling. Researchers study kisspeptin peptides to understand the mechanisms controlling GnRH secretion and downstream reproductive hormone regulation. Because kisspeptin neurons integrate signals from metabolic, hormonal, and environmental pathways, they are considered important regulators of reproductive status.

In reproductive research, kisspeptin is studied as a tool for examining hypothalamic-pituitary-gonadal axis function, including puberty regulation, gonadotropin secretion, ovarian physiology, and male reproductive biology. Human studies have investigated kisspeptin administration in controlled research settings to evaluate hormone responses and reproductive endocrine function.

Additional research has explored potential roles outside reproduction, including metabolic regulation, pancreatic insulin signaling, neural processing, and tissue-specific signaling pathways. These investigations are primarily based on cellular models, animal studies, and limited human experiments.

Research Applications

• Reproductive endocrinology
• Hypothalamic–pituitary–gonadal axis research
• GnRH neuron signaling studies
• Puberty and developmental biology
• Fertility research
• Neuroendocrinology
• Metabolic regulation research
• Pancreatic islet biology
• Behavioural neuroscience
• Hormone signaling research

Potential Scientific Benefits 

Kisspeptin is one of the most extensively studied upstream regulators of reproductive hormone signaling. Vitro studies demonstrate that activation of KISS1R stimulates GnRH neurons, resulting in increased GnRH secretion and subsequent regulation of LH and FSH release. This pathway provides a critical connection between environmental, metabolic, and reproductive signals.

Human clinical studies have investigated kisspeptin administration for evaluating reproductive endocrine function and controlled stimulation of gonadotropin release. Research has explored applications in assisted reproductive technology, hypothalamic reproductive disorders, and diagnostic assessment of GnRH pathway function.

Beyond reproductive physiology, experimental studies suggest that kisspeptin signaling may influence metabolic pathways. Animal models have investigated relationships between KISS1R signaling and glucose metabolism, adipose tissue function, insulin secretion, and energy regulation. Human studies have reported effects on insulin secretion in certain experimental conditions, while effects on appetite and body weight regulation remain uncertain.

Research has also explored kisspeptin involvement in neural processing, sexual behavior, emotional responses, liver fibrosis pathways, and bone metabolism. These findings expand understanding of kisspeptin biology but remain preliminary, with many mechanisms requiring further validation.

Observed biological activities in research

• Stimulation of GnRH secretion through KISS1R activation
• Increased LH and FSH release in experimental settings
• Regulation of reproductive hormone signaling
• Modulation of pancreatic insulin secretion pathways
• Effects on metabolic signaling in animal models
• Alteration of neural responses associated with reproductive behavior

Reported molecular mechanisms

• Activation of KISS1R/GPR54 signaling
• Regulation of hypothalamic GnRH neuron activity
• Modulation of hypothalamic reproductive pathways
• Interaction with metabolic and endocrine signaling networks

Physiological pathways involved

• Hypothalamic–pituitary–gonadal axis
• Gonadotropin regulation
• Reproductive hormone signaling
• Metabolic homeostasis
• Neural signaling pathways
• Endocrine communication networks

Experimental outcomes in models

• Increased GnRH and gonadotropin secretion
• Altered reproductive hormone profiles
• Changes in metabolic markers in animal models
• Modulation of reproductive-related neural activity

Current evidence remains limited, and further well-controlled clinical studies are required to establish long-term efficacy and safety in humans.

Research Data Sheet

• Compound / Peptide Name: Kisspeptin-10 (Kp-10; Human Metastin 45-54)
• Sequence: H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
• Classification: Synthetic neuropeptide fragment
• Molecular Formula: C₆₃H₈₃N₁₇O₁₄
• Molecular Weight: 1302.4 g/mol
• CAS Number: 374675-21-5
• Form: Lyophilized peptide powder
• Appearance: White to off-white lyophilized solid
• Storage: Refrigerated or frozen according to supplier specifications
• Research Categories: Reproductive Biology, Endocrinology, Neurobiology, GnRH Signaling, Fertility Research, Metabolic Research

Safety Precautions 

Kisspeptin is supplied strictly for laboratory research use and should only be handled by qualified personnel following appropriate peptide research procedures. Proper storage, handling, documentation, and contamination control procedures should be followed. The long-term biological effects of experimental kisspeptin exposure and its effects outside controlled research settings have not been fully characterized.

• Research use only
• Not for human consumption
• Not intended to diagnose, treat, or prevent disease
• Wear appropriate PPE including gloves, laboratory coat, and eye protection
• Maintain aseptic handling procedures during preparation
• Store according to recommended temperature conditions
• Avoid repeated freeze–thaw cycles
• Maintain proper labeling and experimental documentation
• Dispose of materials according to institutional and regulatory requirements
• Human safety data are limited to specific controlled research settings
• Potential long-term effects require further investigation

Conclusion 

Kisspeptin is a biologically important neuropeptide that serves as a central regulator of reproductive endocrine signaling through activation of the KISS1R receptor and modulation of GnRH secretion. Its role in coordinating communication between the brain, endocrine system, and reproductive organs has made it a major focus of neuroendocrinology research.

Available evidence includes extensive studies, as well as controlled human investigations examining reproductive hormone regulation. Research suggests that kisspeptin influences reproductive physiology and may also participate in metabolic, neural, and tissue-specific signaling pathways.

Kisspeptin continues to be investigated as a valuable research tool for understanding fertility regulation, hormone signaling, metabolism, and neuroendocrine communication. Although promising biological effects have been reported, many applications remain experimental and require further validation.