KPV – 10mg

Description

KPV – The Anti-inflammatory Peptide 

KPV (Lys-Pro-Val) is a synthetic tripeptide derived from the C-terminal sequence of alpha-melanocyte-stimulating hormone (α-MSH), a naturally occurring melanocortin peptide involved in pigmentation, immune regulation, and inflammatory signaling. As a small bioactive peptide fragment, KPV has been investigated for its potential anti-inflammatory properties while lacking some of the broader receptor-mediated activities associated with the parent α-MSH molecule.

Research suggests that KPV may influence inflammatory signaling pathways through mechanisms that differ from conventional immunosuppressive compounds. Studies have primarily investigated its effects on nuclear factor kappa B (NF-κB) signaling, mitogen-activated protein kinase (MAPK) pathways, oxidative stress responses, and intestinal epithelial function. The peptide has also been studied for its interaction with the peptide transporter PepT1, particularly in inflammatory conditions where intestinal PepT1 expression may be increased.

Preclinical investigations have explored KPV in models of intestinal inflammation, epithelial barrier disruption, oxidative stress, and immune-mediated responses. Findings from cell studies suggest that KPV may reduce production of certain pro-inflammatory mediators and influence tissue protection pathways.

Product Specifications

• Peptide Name: KPV (Lys-Pro-Val)
• Classification: Synthetic tripeptide; α-MSH-derived peptide fragment
• Sequence: Lys-Pro-Val (KPV)
• Molecular Formula: C₁₆H₃₀N₄O₄
• Molecular Weight: 342.43 g/mol
• CAS Number: 67727-97-3
• PubChem CID: 125672
• ChemSpider ID: 111779
• ChEMBL ID: CHEMBL3235483
• DrugBank ID: DB05479
• Form: Lyophilized peptide powder
• Appearance: Typically supplied as a white to off-white lyophilized powder
• Storage: Store according to supplier recommendations, commonly refrigerated or frozen
• Solubility: Research-dependent
• Regulatory Status: Research compound; not approved as a therapeutic medication

What Is It Used For and Its Purpose 

KPV is primarily studied as a molecular research tool for investigating inflammatory regulation, epithelial barrier biology, and immune signaling. Researchers examine the peptide to understand how small endogenous peptide fragments may influence inflammatory pathways without broadly suppressing immune function.

The peptide has been investigated in gastrointestinal research models, particularly those involving intestinal epithelial integrity and inflammatory signaling. Studies have explored whether KPV may influence cytokine production, mucosal barrier responses, and cellular stress pathways associated with intestinal inflammation.

Additional research has examined KPV in skin biology, wound repair models, oxidative stress studies, and immune response regulation. These investigations aim to clarify whether KPV can modulate inflammatory processes at the cellular level and identify potential mechanisms relevant to tissue homeostasis.

Research Applications

• Inflammation research
• Gastrointestinal biology
• Intestinal epithelial barrier research
• NF-κB signaling studies
• MAPK pathway research
• Oxidative stress biology
• Immunology research
• Skin inflammation research
• Tissue repair studies
• Peptide pharmacology

Potential Scientific Benefits 

KPV has been investigated for its potential ability to regulate inflammatory signaling through multiple cellular pathways. In vitro studies suggest that the peptide may inhibit activation of NF-κB, a transcription factor involved in regulating expression of many inflammatory mediators. By reducing NF-κB-related signaling, KPV may influence production of cytokines and other inflammation-associated molecules.

Research has also examined KPV’s effects on intestinal epithelial cells. Experimental models suggest that the peptide may interact with the PepT1 transporter, which can become more active during intestinal inflammation. Through this pathway, KPV has been investigated for possible effects on epithelial barrier maintenance, inflammatory mediator production, and tissue response to cellular stress.

Preclinical studies have reported potential effects on oxidative stress pathways, including reductions in reactive oxygen species generation and modulation of redox-sensitive signaling mechanisms. These findings suggest that KPV may participate in cellular protection pathways, although the significance of these effects in human physiology remains uncertain.

Observed biological activities in research

• Reduction of inflammatory signaling markers in experimental models
• Modulation of NF-κB activation
• Effects on MAPK-associated inflammatory pathways
• Regulation of oxidative stress responses
• Potential support of intestinal epithelial barrier function
• Influence on inflammatory cytokine production

Reported molecular mechanisms

• Inhibition of NF-κB pathway activation
• Modulation of ERK and p38 MAPK signaling pathways
• Interaction with PepT1-mediated cellular transport
• Reduction of reactive oxygen species generation

Physiological pathways involved

• Innate immune signaling
• Cytokine regulation
• Intestinal mucosal homeostasis
• Cellular oxidative stress responses
• Tissue remodeling pathways

Experimental outcomes in models

• Reduced inflammatory markers in cell-based studies
• Improved epithelial barrier-related measurements in animal models
• Altered oxidative stress responses
• Modulation of immune-related signaling pathways

Current evidence remains limited, and further well-controlled clinical studies are required to establish long-term efficacy and safety in humans.

Research Data Sheet 

• Compound / Peptide Name: KPV (Lys-Pro-Val)
• Sequence: Lys-Pro-Val
• Classification: Synthetic tripeptide; α-MSH-derived peptide fragment
• Molecular Formula: C₁₆H₃₀N₄O₄
• Molecular Weight: 342.43 g/mol
• CAS Number: 67727-97-3
• PubChem CID: 125672
• ChemSpider ID: 111779
• ChEMBL ID: CHEMBL3235483
• Form: Lyophilized peptide powder
• Appearance: White to off-white powder
• Storage: Store according to supplier specifications
• Research Categories: Inflammation Research, Immunology, Gastrointestinal Biology, Peptide Pharmacology, Oxidative Stress Research, Tissue Repair Studies

Safety Precautions 

KPV is supplied strictly for laboratory research use and should only be handled by trained personnel following appropriate laboratory safety procedures. Laboratory handling should follow standard peptide research practices, including appropriate storage, documentation, contamination control, and disposal procedures. The biological effects of KPV in humans have not been fully characterized.

• Research use only
• Not for human consumption
• Not intended to diagnose, treat, or prevent disease
• Use appropriate PPE including gloves, laboratory coat, and eye protection
• Maintain aseptic handling requirements during preparation
• Store under recommended temperature conditions
• Avoid repeated freeze–thaw cycles
• Ensure proper labeling and experimental documentation
• Dispose of materials according to institutional and regulatory requirements
• Limited human safety data are available
• Potential unknown long-term biological effects remain under investigation

Conclusion 

KPV is a small synthetic tripeptide derived from α-MSH that has attracted research interest due to its potential role in regulating inflammatory signaling, epithelial barrier function, and cellular stress responses. Its simple structure and relationship to endogenous melanocortin peptides make it a useful compound for investigating peptide-based approaches to inflammatory biology.

Research findings suggest that KPV may influence NF-κB signaling, MAPK pathways, oxidative stress responses, and intestinal epithelial mechanisms. KPV continues to be investigated as a research peptide in areas including immunology, gastrointestinal biology, tissue repair, and molecular inflammation pathways.